Clindamycin Phosphate CAS 24729-96-2
Directory Guidance on Clindamycin Phosphate
Name: Clindamycin Phosphate
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Clindamycin phosphate, also known as Cleocinphosphate, chemical name: 6-(1-methyl-trans-1-propyl-L-2-pyrrolidinecarboxamido)-1-thio-7(S) -Chloro-6,7,8-trideoxy-L-threo-α-D-galactooctanopyranoside-2-dihydrogen phosphate. It is a chemical semi-synthetic clindamycin derivative, which rapidly hydrolyzes clindamycin in vivo to show pharmacological activity.
Clindamycin phosphate is a white or off-white crystalline powder at room temperature, odorless, bitter in taste, and hygroscopic. Soluble in water and dilute lye, slightly soluble in methanol, almost insoluble in ethanol and ether.
High blood concentration can be obtained immediately after administration by injection, and then it is widely distributed in tissues and body fluids, such as lung, tonsil, liver and gallbladder, peritoneal fluid, appendix, prostate and uterus and fallopian tubes. Can reach high concentrations, especially in bone and joint tissue is characterized by higher concentrations. However, the ability to penetrate the blood-cerebrospinal liquid obstacle is poor, as well as the concentration in mind tissue is reduced.
It has no anti-bacterial task in vitro, as well as can be rapidly hydrolyzed right into clindamycin after going into the body to apply its medicinal impact. Its mechanism of activity, antibacterial spectrum, signs, as well as therapeutic results coincide as those of clindamycin. Nevertheless, its fat solubility as well as permeability are much better than that of clindamycin, and also it can be carried out by mouth or intramuscularly as well as intravenously.
Compared to clindamycin, clindamycin phosphate has 4 to 8 times stronger anti-bacterial impact, good absorption, high bone cells focus, and also strong antibacterial activity against Gram-positive cocci and anaerobic microorganisms.
Its antibacterial range is:
Gram-positive cocci consist of penicillin G-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus (other than Streptococcus phosphate), Streptococcus pneumoniae, Micrococcus, etc.
Gram-positive bacilli consist of Clostridium, Diphtheria, and the like.
Anaerobic microorganisms include Clostridium, Bacteroides, Clostridium, Propionibacterium, Eubacterium, anaerobic cocci and so forth.
Nature and Specifications:
- Density: 1.41 g/cm3
- Melting point: 114ºC
- Boiling point: 159°C
- Refractive index: 122 ° (C=1, H2O)
- Storage conditions: Sealed in dry, 2-8°C
- Solubility: soluble224mg/mL at 25°C
- Water solubility: Freely soluble in water
Used in the manufacture of medicines to deal with inflammation
Clinically, clindamycin phosphate is mainly made use of to deal with tonsillitis, suppurative otitis media, sinus problems, severe bronchitis, severe worsening of chronic respiratory disease, pneumonia, lung abscess, bronchiectasis challenging infection and skin and soft tissue infection.
Such as furuncle, carbuncle, abscess, cellulitis, injury infection, shed infection, postoperative infection, etc. And urinary tract acute urethritis, acute pyelonephritis, prostatitis and so on. Also used for osteomyelitis, sepsis, peritonitis, oral infections, etc.
Clindamycin phosphate enters the body and acts, mainly metabolized in the liver, excreted in bile and feces, and partially excreted in urine.
used as an antibiotic
Clindamycin phosphate is a broad-spectrum antibiotic with both anti-anaerobic and aerobic effects. With the exception of Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus viridans as well as a lot of Staphylococcus aureus methicillin-resistant pressures, a lot of anaerobic germs are effective.
It is scientifically used for abdominal and also pelvic infections caused by anaerobic germs including Bacteroides fragilis, Clostridium perfringens, Actinomyces, and so on, as well as respiratory system system, joint as well as soft tissue, bone cells caused by delicate Gram-positive bacteria. biliary system infection and also sepsis, endocarditis and more.
Compared with clindamycin, its effect has the features of high anti-bacterial task, rapid absorption, solid lipid solubility and leaks in the structure, and much less side effects. It is extensively distributed in the body as well as has high tissue concentration, especially in bone tissue. It has solid antibacterial result on all sort of Gram-positive germs and also has few side effects.
- “Clindamycin Phosphate Retinoic Acid Gel for Acne Treatment” – NIH, PubMed | 2019 Apr 1.
- “Effects of selected antibiotics on oxonase in vitro in human serum and in vivo in mouse serum and liver” – NIH, PubMed | 2006 Aug.
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
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7. Free Sample
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The clindamycin phosphate produced by our company has stable performance and a wide range of uses, which can meet the various needs of different customers.
The product price is competitive, and it has a good reputation and market share in countries all over the world.
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