TCEP HCl CAS 51805-45-9
Name: TCEP HCl Powder
Cas: 51805-45-9
Purity:Â 99%min
MOQ: 1KG
Basic Info:
| CAS No: | 51805-45-9 |
| Formula: | C9H16ClO6P |
| EINECS: | 629-759-1 |
| Stock Availability | In stock |
| Brand Name | Zhishang chemical |
| Origin | China |
Chemical Structure
Product Introduction:
TCEP (tris(2-carboxyethyl)phosphine) is a decreasing agent typically used in molecular and biochemical biology applications. It is usually prepared and used as the hydrochloride salt (TCEP-HCl) with the molecular formula C9H16ClO6P. TCEP HCl is soluble in water, available as a stable solution at neutral pH, and immobilized on an agarose carrier to facilitate removal of reducing agents.
TCEP HCl is a colorless, odorless, weakly reducing substance soluble in water, the solubility in water can reach 310mg/mL. It has high stability in air and aqueous solution, and is less affected by temperature and concentration.
Except for cysteine, there are almost no side reactions with other amino acids. And TCEP HCl can be used in a wider pH range including acidic conditions (pH value 3), thereby effectively reducing the hydrolysis of amide bonds. It has the best effect among trivalent phosphorus derivatives.
TCEP HCl has mild reactivity, easy solubility, low toxicity, easier operation, and good stability in acidic and alkaline solutions. It is also more stable than DTT in mass spectrometry applications. It can additionally be utilized for careful reduction of disulfides in water.
Nature and Specifications:
- Density: 1.041 g/mL at 25 °C
- Boiling point: 519.4ºC at 760 mmHg
- Melting point: 177 °C
- Flash point: 267.9ºC
- Refractive index: n20/D 1.367
- Acidity coefficient (pKa): 7.66 (at 25℃)
- Storage conditions: 2-8ºC
| Item | Specification |
| Product Name | TCEP HCl Powder |
| CAS No. | 51805-45-9 |
| Appearance | White crystalline powder |
| Shelf Life | 2 years |
| Packing | 1kg/bag,25kg/bag or as your requirements |
Product Packaging
Product Usage:
Tris (2-carboxyethyl) phosphine hydrochloride (TCEP HCl) has important uses in medicine. It is a unique thiolated DNA deprotection and reducing agent. Thiolated DNA terminal sulfur atoms tend to dimerize in use, especially in the presence of oxygen. This dimerization can greatly reduce the efficiency of some coupling reaction experiments, such as DNA immobilization in biosensors.
However, adding tris(2-carboxyethyl)phosphine hydrochloride to the DNA service and removing it after a period of reaction can reduce DNA dimerization. TCEP HCl is also commonly used to reduce disulfide bonds in healthy proteins, and it can also be used to prevent intramolecular or intermolecular disulfide bonds that develop between cysteines in proteins.
TCEP hydrochloride is a trialkylphosphine that selectively reduces protein breakdown without altering its properties or interacting with thiol directing agents in the reaction mixture.
In addition to this, TCEP HCl is an organophosphorus compound and can be used as a water-soluble reagent.
TCEP HCl has stronger reducing ability than DTT, is more stable than DTT, and is not easily oxidized by air. Its effect can be maintained for 2 to 3 weeks and is recognized as a good substitute for DTT (dithiothreitol).
Related References:
- “The role of novel disulfide bonds in soluble Rieske proteins” – springer, Link | 28 October 2009.
- “Crosslinking of Human Plasma C-Reactive Protein to Human Serum Albumin via Disulfide Oxidation” – NIH, PubMed | 2021 May.
- Wikipedia
Product Service:
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
6. Packing pictures and loading video before loading
7. Free Sample
8. Factory audit
Our Metrics
Our factory has advanced product production lines, and stable production capacity, which can achieve the goal of quickly providing high-quality products.
Our company is equipped with first-class equipment for the product production line to ensure the product quality to the greatest extent, to ensure that the net weight of the product is accurate, the packaging is well sealed, and it can meet the needs of long-distance transportation for export.
The TCEP HCl produced by our company has stable performance and a wide range of uses, which can meet the various needs of different customers.
The product price is competitive, and it has a good reputation and market share in countries all over the world.
If you need TCEP Hydrochloride or related products, please contact our company directly. Professional production and perfect service will definitely make you satisfied.
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.
- After delivery, we will send a set of scanned copies of shipping documents to customers by mail, and mail the original documents in time. After the ship leaves the port, we update the shipping schedule to the customer every week and tell the customer when to arrive at the port. If customers encounter customs clearance problems, we will actively cooperate with customers to solve them. If it is an air or express delivery customer, we will provide the customer with the tracking number in time and update the information in time.
- After the customer receives the goods, we will promptly communicate with the customer about the quality and packaging of the product. Hope to get feedback from customers.
- We will provide customers with domestic market conditions and update prices in a timely manner. If conditions permit, we will also provide customers with the demand for the product in the country where they are located to help customers occupy the market.
- If there is any product quality problem, we will solve it in time. Compensation will also be made to the customer according to the third-party test report made by the customer. At present, the compensation rate due to quality objection is less than 1%.
- For our VIP customers, we have a very big preferential policy. If there is a quality problem with the product, we will be exempted from investigation and compensation, no more than three times a year.
- For ordinary customers, we will review the information provided by the customer, and then make compensation.
- Free samples can be provided before customers place an order.
- Customers can contact our technical staff at any time if they have any professional questions they do not understand. Technicians are online 24 hours a day.
DO YOU ACCEPT SAMPLE ORDER?
We will make samples before mass production. After the samples are approved by the department and users, we will start mass production. During the production process, we will carry out 100% inspection, and then carry out random inspection before packaging.
WHAT’S YOUR MOQ?
Our MOQ is 1kg. But usually we can also accept a smaller quantity, such as 100g, if you need it, provided that the sample fee is 100% paid.
IS THERE A DISCOUNT?
Different quantity has different discount.
DO YOU SUPPLY PRODUCT REPORT?
Yes. We’ll give you product analysis report before shipping.
