Tris Base CAS 77-86-1

Name: Tris Base Powder

Cas: 77-86-1

Purity: 99%min

MOQ: 1KG

Basic Info:

CAS No:77-86-1
Formula:C4H11NO3
EINECS:201-064-4
Stock AvailabilityIn stock
Brand NameZhishang chemical
OriginChina

Chemical Structure

Tris Base

Product Introduction:

Tris Base full name: Tris(hydroxymethyl)aminomethane, also known as tromethamine, Trometamol, typically described as Tris, is an organic substance with the molecular formula (HOCH2)3CNH2. Tris Base is a white crystal or powder. Soluble in ethanol and also water, slightly soluble in ethyl acetate and also benzene, insoluble in ether and carbon tetrachloride, destructive to copper as well as aluminum, and bothersome chemicals.

Tris Base is a weak base with a pKa of 8.1 at 25 ° C. According to buffer theory, the effective buffering series of Tris barrier is in between pH 7.0 and also 9.2. The pH of the aqueous option of Tris base has to do with 10.5. Generally, hydrochloric acid is added to adjust the pH value to the preferred value, and after that the buffer solution with the pH worth can be acquired. Nevertheless, focus must be paid to the result of temperature on the pKa of Tris.

Tromethamine is a sodium-free amino buffered base, which reacts with H2CO3 in body fluids to reduce H2CO3 and generate HCO32- at the same time. It can absorb hydrogen ions and correct acidemia. It has a strong effect and can penetrate It is commonly used in acute metabolic and respiratory acidemia.

Nature and Specifications:

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Product Usage:

Tris Base is mainly used as pharmaceutical intermediates, biochemical reagents, as well as pharmaceutical raw materials and acid-base balance regulators. For intense respiratory system, metabolic acidemia.

Tris Base is extensively utilized in intense metabolic as well as respiratory system acidemia. It is an alkaline barrier as well as has a great buffering impact on metabolic acidosis and also enzymatic task. Tromethamine is an organic reagent, a barrier service generally used in organic preparation and clinical preparation.

Tris Base buffer solution is also widely used as a solvent for nucleic acids, proteins, electrophoresis solvents, etc., and the amount is large. However, this buffer solution is not easy to store for a long time, the concentration of the stock solution is low, and the number of times of use is also small.

At present, Trometamol is commonly made use of in the prep work of buffers in biochemical and also molecular biology experiments. For example, Tris is required in both TAE and TBE buffers (for solubilization of nucleic acids) commonly used in biochemical experiments. Because Tris Base has amino teams, it can go through condensation reactions with aldehydes.

When used as a biological buffer and a reference substance for acid titration, the purity requirements are relatively high, generally 99.9%-100%.

Related References:

  1. “Allergy to Moderna COVID-19 Vaccine Caused by Tromethamine” – JIACI | Excerpt: April 28, 2022.
  2. “Chemistry and Pharmacology of Tris Base” – Springer, Link | Excerpt: April 28, 2022.
  3. Wikipedia

Product Service:

1. Certificate Of Analysis (COA)

2. Material Safety Data Sheet (MSDS)

3. Route of synthesis (ROS)

4. Method of Aanlysis (MOA)

5. Nuclear Magnetic Resonance (NMR)

6. Packing pictures and loading video before loading

7. Free Sample

8. Factory audit

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The Tris Base produced by our company has stable performance and a wide range of uses, which can meet the various needs of different customers.

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