Quercetin in Plants | Actions & Effects on Human Body

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Quercetin in Plants

Quercetin, the dihydrate is a yellow needle-like crystal, which becomes anhydrous at 95-97 ° C. Soluble in ethanol, methanol, ethyl acetate, antarctic acetic acid, pyridine, acetone, etc, nearly insoluble in water, benzene, ether, chloroform, oil ether, and so on.

Quercetin is widely discovered in angiosperms, such as red tube medication, feline’s eye lawn, iron-coated gold, manshan red, loquat, purple azalea, Zhaoshan white, dwarf tea, and also apocynum. This substance is an aglycone, which is often incorporated with sugar in the form of glycosides, such as quercetin, rutin, hypericin, etc.

Foods abundant in quercetin include: tea, capers, angelica, apples, red onions, red grapes, citrus, tomatoes, broccoli, as well as various other green leafy vegetables. There are also high degrees of lots of berries, including those of raspberries, bilberries, cranberries, sea buckthorn, crowberry, and also cactus.

Quercetin has excellent expectorant and antitussive results, and also has particular anti-asthmatic effects. In addition, it also has the effects of reducing blood pressure, lowering capillary frailty, boosting its resistance, lowering blood lipids, expanding coronary arteries, and also boosting coronary blood flow.

Quercetin in Plants

Medicinal Activity

Quercetin can dramatically prevent health hazards, isolated malignant cells, Ehrlich ascites cancer cells DNA, RNA and protein synthesis and also development. It has obvious repressive impact on platelet gathering generated by different aspects, and also can prevent the release of serotonin.

The intro of hydrophilic teams into quercetin can boost its water solubility, which is a lot more conducive to absorption, consequently enhancing medicinal effects, such as the rise in water solubility of quercetin oxyacetic acid lysine salt. Scientific trials have revealed that it can be utilized to treat bleeding conditions, circulatory problems, atherosclerosis, and the like.

Quercetin obstructs the activity of androgens on hormone-dependent human prostate cancer cells, and when the activity of androgens is obstructed, the development of prostate cancer cells is reduced or stopped.

Quercetin is an over-the-counter medicine for prostate cancer in the United States, yet it has actually not been accepted as a prostate treatment in China.

Quercetin Uses

Quercetin can influence the expansion, transition, apoptosis and metabolism of growth cells with several signaling paths, as well as has inhibitory impacts on numerous tumors such as intestines cancer cells, stomach cancer, breast cancer cells and leukemia.

Quercetin is used in the therapy of chronic respiratory disease, and additionally has an adjuvant treatment effect on people with coronary heart disease as well as high blood pressure.

Quercetin can additionally be used in various other sectors. As an antioxidant, it is primarily made use of in oils, beverages, cold beverages, and also processed meat products.

As a natural dye, it can be used as a medium dye for woollen and also cotton, using aluminum salts to get yellow, utilizing chromium salts to get olive yellow, utilizing tin salts to acquire orange, and utilizing iron salts to acquire olive green.

The Impact of Quercetin on the Human Body

As the most typical flavonoids, quercetin has a selection of organic activities, can withstand oxidation, and also plays a crucial function in the medical therapy of cancer as well as cardiovascular diseases.

1. Antioxidant feature

Quercetin not just joins anti-oxidation in vitro as well as can prevent oxidative damage to DNA, but also safeguards cells from oxidative damage in vivo by lowering the concentration of peroxides in cells.

2. Anti-cancer result

On the one hand, quercetin can properly prevent the generation of cost-free radicals. Its flavonoids such as quercetin can substantially decrease the occurrence of gastric cancer, straight hinder the growth of cancer cells or might act upon the cell transduction pathway of cancer cell expansion.

On the other hand, it can boost the impact of anticancer drugs and also considerably boost the efficiency.

3. Safeguard cardio

The 3rd significant impact of quercetin is cardiovascular security. It is generally reflected in 5 facets:

  1. Expand blood vessels, reduced blood pressure;
  2. Avoidance and also treatment of coronary cardiovascular disease: Via animal experiments, the features of minimizing the occurrence as well as death of coronary infarction as well as blood glucose have additionally been located;
  3. Decrease myocardial hypertrophy;
  4. Prevent the expansion as well as hypertrophy of vascular smooth muscle cells;
  5. Antithrombotic.

various other

On top of that, quercetin also has neuroprotective, anti-inflammatory, as well as antiviral effects.

Anti-inflammatory impact: When the human immune system battles bacterial invasion, lipopolysaccharide (LPS) can cause the body’s immune action and also inflammatory reaction. Numerous researches have actually shown that quercetin has an inhibitory effect on the inflammatory reaction caused by LPS.

Antibacterial impact: Quercetin is also a broad-spectrum antibacterial material, which can be utilized to prevent as well as deal with different microbial transmittable diseases.

Antiviral result: Quercetin can deal with versus a variety of viruses, such as HIV virus, anti-sarcoma infection, human herpes simplex infection, parainfluenza infection kind 3 (Pf-3), respiratory system syncytial infection (RSV).

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Burak, C., Brüll, V., Langguth, P. et al. Higher plasma quercetin levels following oral administration of an onion skin extract compared with pure quercetin dihydrate in humans. Eur J Nutr 56, 343–353 (2017). 

Avinash B, Venu R, Prasad TNVKV, Alpha Raj M, Srinivasa Rao K, Srilatha C. Synthesis and characterisation of neem leaf extract, 2, 3-dehydrosalanol and quercetin dihydrate mediated silver nano particles for therapeutic applications. IET Nanobiotechnol. 2017 Jun;11(4):383-389. doi: 10.1049/iet-nbt.2016.0095. PMID: 28530186; PMCID: PMC8676007.


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