Bulk Nicotinamide Powder CAS 98-92-0 | High Purity Vitamin B3 Supplier
Product Introduction of Nicotinamide
Chemical Properties and Quality Specifications
To maintain formulation stability and prevent skin sensitization caused by impurities, strict control over chemical parameters—particularly residual nicotinic acid—is maintained during our manufacturing process.
Chemical Name: Pyridine-3-carboxamide (Nicotinamide / Niacinamide)
CAS Number: 98-92-0
Molecular Formula: C6H6N2O
Molecular Weight: 122.12 g/mol
Appearance: White crystalline powder or needle-like crystals
Assay (Purity): 99.0% – 101.0% (Calculated on dried basis via HPLC / Titration)
Melting Point: 128°C – 131°C
Free Nicotinic Acid Limit: <= 0.1% (Strictly controlled to prevent flushing in topical formulations)
Loss on Drying: <= 0.5%
Residue on Ignition: <= 0.1%
Heavy Metals: <= 10 ppm (Lead <= 2 ppm, Arsenic <= 1 ppm)
Solubility: Freely soluble in water (1 g/1 mL) and ethanol; soluble in glycerol; insoluble in ether.
Product Packaging
Application of Nicotinamide
Related Questions:
Q1: How do you control the level of residual nicotinic acid in your Nicotinamide powder?
Q2: Is your Nicotinamide suitable for vegan and non-GMO formulations?
Yes. Our production process utilizes purely synthetic raw material routes without animal-derived inputs or genetically modified organisms.
Q3: What is the standard shelf life of Nicotinamide powder?
Q4: What is the MOQ for commercial procurement?
Our standard MOQ for commercial orders is 25 kg (one full drum). Sample quantities ranging from 100g to 1kg are available for laboratory validation and formulation testing.
Manufacturing Precision and Quality Assurance
Our manufacturing infrastructure operates under stringent ISO and GMP-aligned quality management systems. Synthetic pathways are optimized to ensure complete conversion, followed by multi-stage recrystallization to remove trace organic impurities and heavy metals.
Every commercial lot undergoes rigorous testing prior to release:
Purity & Related Substances: High-Performance Liquid Chromatography (HPLC) verifying structural purity and monitoring trace nicotinic acid levels.
Structural Identification: Infrared Absorption Spectroscopy (FTIR) and Nuclear Magnetic Resonance (NMR) confirmation.
Physical Testing: Melting point determination, particle size distribution analysis, and bulk density measurement.
Trace Contaminants: Inductively Coupled Plasma Mass Spectrometry (ICP-MS) for heavy metal profiling.
Formulators should observe the following technical considerations to maintain product integrity within final liquid or solid bases:
Thermal Stability: Nicotinamide is thermally stable in dry powder form. In aqueous solution, avoid prolonged exposure to temperatures above 80°C under strongly acidic or basic conditions to prevent hydrolysis into nicotinic acid.
pH Range: Optimal solution stability occurs between pH 5.0 and 7.0. At pH levels below 3.5 or above 8.5, hydrolytic cleavage of the amide group can occur over time.
Light and Moisture Sensitivity: Hygroscopic in nature under high humidity environments. Keep bulk containers tightly sealed in dry storage.
Nicotinamide (CAS: 98-92-0) supplied by Organic Intermediate is distributed exclusively as an industrial raw material for cosmetic formulation, chemical manufacturing, feed processing, and research applications.
Regulatory Documentation: Each shipment includes a comprehensive technical dossier consisting of a Lot-Specific Certificate of Analysis (COA), Safety Data Sheet (SDS / MSDS), Non-GMO Statement, Allergen Declaration, and BSE/TSE-Free Certificate.
Regulatory Notice: Finished-product manufacturers are responsible for verifying compliance with applicable regional regulatory frameworks (such as US FDA cosmetic guidelines, EU Cosmetic Regulation EC No 1223/2009, or national authorities).
Packaging Options: Standard supply is packaged in 25 kg fiber drums with double food-grade polyethylene inner liners. Sample quantities (1 kg, 5 kg) are available in heat-sealed aluminum foil bags for laboratory evaluation.
Storage Conditions: Store in cool, dry, well-ventilated warehouses away from direct sunlight, moisture, and incompatible oxidizing materials. Recommended storage temperature: 15°C to 25°C.
Manufacturer of Nicotinamide
API, usually referring to chemical raw materials, is the active ingredient in chemical drug formulations.
Nicotinamide Safety Information
| Hazard Codes | Xi,T,F |
| Risk Statements | 36/37/38-39/23/24/25-23/24/25-11 |
| Safety Statements | 26-36-37/39-45-36/37-16-7 |
| RIDADR | UN1230 – class 3 – PG 2 – Methanol, solution |
| WGK Germany | 1 |
| RTECS | QS3675000 |
| F | 8 |
| Autoignition Temperature | 480 °C |
| TSCA | TSCA listed |
| HS Code | 29362990 |
| Storage Class | 11 – Combustible Solids |
OrganicIntermediate is a professional foreign trade enterprise specializing in chemical raw materials. Upholding people-oriented values and cooperating with reliable manufacturers, we aim to become the world’s most trusted chemical supplier. Our production plant is located 50 meters south of the intersection of North Ring Road and 13th Road, Chenwang Street, Juancheng County, Heze City, Shandong Province. Our R&D laboratory is situated at R&D Base : F5, Yinfeng Biomedical City, Free Trade Zone, Jinan, Shandong. Integrating R&D and production, we strictly control product quality. With stable supply and sincere service, we welcome global customers for consultation and procurement.
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This article was written by William, the chief chemist of Shandong Zhishang New Materials Co., Ltd.
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