Bulk Bromelain Powder CAS 9001-00-7 | High Activity Proteolytic Enzyme Manufacturer
Product Introduction of Bromelain
Technical Specifications and Physical Parameters
Detailed physical parameters and activity standardization metrics are essential for formulation engineers balancing substrate hydrolysis rates against process temperature and pH constraints.
Chemical Name: Bromelain (Stem / Fruit Protease)
CAS Number: 9001-00-7
EINECS Number: 232-627-2
Source: Ananas comosus (Stem extract)
Appearance: Off-white to light yellow free-flowing powder
Enzymatic Activity Range: 600 GDU/g to 2400 GDU/g (Custom activity standardization available)
Optimum Temperature: 40°C – 55°C (Rapid thermal denaturation occurs above 65°C)
Optimum pH Range: 5.5 – 7.5 (Functional stability maintained between pH 4.0 and 8.0)
Solubility: Soluble in water, yielding a slightly turbid colloidal solution; insoluble in ethanol, ether, and chloroform.
Product Packaging
Application of Bromelain
Related Questions:
Q1: What is the difference between GDU/g and MCU/g activity units for Bromelain?
Q2: How should Bromelain be stored to prevent activity loss over time?
Unopened Bromelain powder should be stored under dry, refrigerated conditions (2°C – 8°C). When stored properly, annual activity decay is minimized to less than 3-5% per year.
Q3: Can Bromelain be supplied in custom activity strengths?
Q4: What standard documentation accompanies commercial shipments?
Each shipment is accompanied by a batch-specific Certificate of Analysis (COA) detailing enzyme activity, moisture content, heavy metals, micro-testing, and a Safety Data Sheet (SDS).
Enzymatic Activity Assays & Quality Verification
Because raw botanical enzymes vary naturally, every production batch of Bromelain undergoes multi-point analytical validation to guarantee declared activity levels:
Activity Determination: Gelatin Digesting Units (GDU/g), Milk Clotting Units (MCU/g), or FIP units evaluated via standardized spectrophotometric substrate digestion.
Purity & Composition: SDS-PAGE gel electrophoresis to confirm structural protein band consistency.
Moisture & Loss on Drying: Karl Fischer titration and loss on drying (LOD <= 5.0%) to prevent premature activity loss during storage.
Heavy Metals & Microbiological Control: ICP-MS for heavy metals (Lead, Arsenic, Cadmium, Mercury) and bioburden testing (Total Viable Count, Salmonella, E. coli) ensuring compliance with international raw material safety thresholds.
To maintain full catalytic efficacy during bulk blending and manufacturing, formulators should observe the following handling parameters:
Temperature Management: Avoid exposing dry powder or aqueous solutions to temperatures exceeding 60°C for extended periods to prevent irreversible enzyme inactivation.
Moisture Control: Bromelain is hygroscopic. Keep containers tightly sealed when not in use to avoid moisture absorption, which accelerates auto-proteolysis.
pH Buffering: Maintain process media within the optimal pH window (5.5 – 7.5) for maximum conversion velocity during hydrolysis operations.
Bromelain (CAS: 9001-00-7) supplied by Organic Intermediate is distributed strictly as a raw material for industrial processing, food formulation, agricultural blending, and manufacturing applications.
Regulatory Package: Complete documentation accompanies every shipment, including Batch Certificate of Analysis (COA), Safety Data Sheet (SDS/MSDS), Non-GMO Certification, Allergen Statement, and Halal/Kosher certificates where applicable.
Regulatory Notice: Formulators and finished product manufacturers are responsible for verifying that their end products meet local food, feed, cosmetic, or dietary supplement compliance criteria (such as US FDA GRAS, EU EFSA, or local regulatory bodies).
Standard Packaging: Packed in multi-layer moisture-barrier aluminum foil bags enclosed in 1 kg tins, 5 kg foil packs, or 25 kg fiber drums.
Storage Conditions: Store in a sealed container in a cool, dry place. Long-term storage at refrigerated temperatures (2°C – 8°C) is recommended to maintain maximum enzymatic activity over extended periods.
Manufacturer of Bromelain
API, usually referring to chemical raw materials, is the active ingredient in chemical drug formulations.
Bromelain Safety Information
| Hazard Codes | B,Xn |
| Risk Statements | 36/37/38-42 |
| Safety Statements | 22-24-26-36/37-36/37/39 |
| WGK Germany | 3 |
| F | 10-21 |
| TSCA | TSCA listed |
| HS Code | 35079090 |
OrganicIntermediate is a professional foreign trade enterprise specializing in chemical raw materials. Upholding people-oriented values and cooperating with reliable manufacturers, we aim to become the world’s most trusted chemical supplier. Our production plant is located 50 meters south of the intersection of North Ring Road and 13th Road, Chenwang Street, Juancheng County, Heze City, Shandong Province. Our R&D laboratory is situated at R&D Base : F5, Yinfeng Biomedical City, Free Trade Zone, Jinan, Shandong. Integrating R&D and production, we strictly control product quality. With stable supply and sincere service, we welcome global customers for consultation and procurement.
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This article was written by William, the chief chemist of Shandong Zhishang New Materials Co., Ltd.
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