Resmetirom Powder CAS 920509-32-6 | High Purity R&D Intermediate Supplier

Resmetirom Powder CAS 920509-32-6 | High Purity R&D Intermediate Supplier

CAS 920509-32-6 | Resmetirom

CAS No:920509-32-6
Formula:C17H12Cl2N6O4
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Stock Availability:In stock
Brand Name:Zhishang New Materials
Origin:China
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Product Introduction of Resmetirom

Resmetirom (CAS: 920509-32-6) is a highly selective, orally active thyroid hormone receptor beta (THR-β) agonist utilized extensively as an active pharmaceutical ingredient (API) reference standard and advanced intermediate in medicinal chemistry and biochemical research. Chemically designated as 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile, this small molecule represents a key compound in targeted metabolic assay studies and formulation development.
 
At Zhishang New Materials, we specialize in the synthesis and supply of high-purity Resmetirom powder (CAS: 920509-32-6). Our stringent quality control protocols ensure exceptional batch-to-batch consistency, enabling researchers, CROs, and analytical laboratories to conduct precise experimental assays and drug development workflows.

Comprehensive Specification & Analytical Sheet

Accurate physicochemical data is critical for analytical validation, solubility screening, and synthetic integration.

  • Chemical Name: 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

  • CAS Number: 920509-32-6

  • Molecular Formula: C17H12Cl2N6O4

  • Molecular Weight: 435.22 g/mol

  • Physical Appearance: White to off-white solid powder

  • Assay (Purity): >= 99.0% (HPLC)

  • Melting Point Range: 215°C – 220°C (with decomposition)

  • Solubility Profile: Soluble in dimethyl sulfoxide (DMSO) and dimethylformamide (DMF); sparingly soluble in anhydrous ethanol; practically insoluble in water.

  • Storage Condition: Store at -20°C in a dry, dark place under inert gas to prevent atmospheric oxidation or moisture degradation.

Product Packaging

Resmetirom Powder CAS 920509-32-6 | High Purity R&D Intermediate Supplier

Application of Resmetirom

Resmetirom is supplied strictly for laboratory research, analytical testing, and chemical synthesis pathways:
 
Target Receptor Profiling & Assay Validation
Researchers employ Resmetirom as a selective reference tool in binding assays to study receptor selectivity dynamics between THR-β and THR-α isoforms in cellular models.
 
Analytical Standard & Impurity Profiling
Analytical laboratories utilize high-purity Resmetirom powder to establish quantitative HPLC profiles, develop stability-indicating methods, and synthesize related structural degradation products.
 
Intermediate for Derivative Syntheses
Medicinal chemistry teams use the core triazinedione-pyridazinone framework of Resmetirom as a starting block for designing novel bioisosteric derivatives and structure-activity relationship (SAR) libraries.
Our standard research-grade Resmetirom is guaranteed at >= 99.0% purity as determined by HPLC. Custom purity grades up to 99.5% can be prepared for specialized analytical requirements.

Resmetirom exhibits optimal solubility in high-purity DMSO (up to 25 mg/mL under light sonication). We recommend preparing fresh stock solutions and storing aliquots at -80°C to minimize freeze-thaw cycles.

Each order includes a comprehensive Certificate of Analysis (COA) specifying exact HPLC purity, 1H-NMR spectrum, LC-MS characterization, residual solvent analysis, and a complete Safety Data Sheet (SDS).

Standard catalog quantities (up to 100 g) are typically maintained in stock for prompt dispatch. Bulk synthesis quantities are subject to production scheduling and can be quoted directly by our sales team.

Quality Assurance & Testing Standards

To support compliance requirements for R&D projects, every batch of Resmetirom (CAS: 920509-32-6) undergoes multi-instrument verification prior to packaging:
 
Purity & Related Substances: High-Performance Liquid Chromatography coupled with Diode Array Detection (HPLC-DAD).
 
Molecular Identity: Proton Nuclear Magnetic Resonance (1H-NMR) and Mass Spectrometry (LC-MS) spectrum matching.
 
Elemental & Residual Analysis: Loss on drying (LOD) evaluation and residual solvent quantification via Headspace Gas Chromatography (HS-GC).
 
A detailed lot-specific Certificate of Analysis (COA), 1H-NMR spectra, and HPLC chromatogram accompany all shipments.

  • Standard Packaging Options: Available in 100 mg, 1 g, 10 g, 100 g, and 1 kg sealed amber glass vials or high-density aluminum foil pouches with desiccants.

  • Custom Quantities: Custom synthesis lots and larger multi-kilogram bulk quantities can be produced upon request to support pilot-scale projects.

  • Global Shipping: Shipped via temperature-controlled express air courier with complete hazardous material documentation, Safety Data Sheets (SDS), and customs declaration paperwork.

Manufacturer of Resmetirom

Articles Related To API

📝API, usually referring to chemical raw materials, is the active ingredient in chemical drug formulations.

Regulatory Disclaimer and Safe Handling

Regulatory Notice: Resmetirom (CAS: 920509-32-6) provided by Organic Intermediate is intended solely for laboratory research, development, and industrial manufacturing uses. It is not intended for human consumption, direct clinical administration, household use, or diagnostic purposes. Formulators and purchasing organizations are responsible for ensuring compliance with local regulatory guidelines regarding the procurement and handling of active chemical substances.
 
Industrial Hygiene: Handle only in certified chemical fume hoods. Laboratory personnel must wear appropriate gloves, protective eye gear, and lab coats to avoid direct dermal contact, dust inhalation, or accidental ingestion.
OrganicIntermediate

OrganicIntermediate is a professional foreign trade enterprise specializing in chemical raw materials. Upholding people-oriented values and cooperating with reliable manufacturers, we aim to become the world’s most trusted chemical supplier. Our production plant is located 50 meters south of the intersection of North Ring Road and 13th Road, Chenwang Street, Juancheng County, Heze City, Shandong Province. Our R&D laboratory is situated at R&D Base : F5, Yinfeng Biomedical City, Free Trade Zone, Jinan, Shandong. Integrating R&D and production, we strictly control product quality. With stable supply and sincere service, we welcome global customers for consultation and procurement.

Our Laboratory
Laboratory and Gas Chromatograph at Shandong Zhishang New Materials Co., Ltd.
Our Factory
The factory of Shandong Zhishang New Materials Co., Ltd.
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This article was written by William, the chief chemist of Shandong Zhishang New Materials Co., Ltd.
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