Buy 1-Methyl-3-phenylpropylamine (CAS 22374-89-6) Bulk Supply

Fast-Track Chemical Procurement: Looking for a certified manufacturer and global exporter of high-purity 1-Methyl-3-phenylpropylamine (CAS 22374-89-6)? We provide factory-direct pricing, flexible batch sizes from grams to metric tons, and comprehensive regulatory documentation (COA, MSDS, NMR, HPLC).

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Overview and Chemical Specifications of 1-Methyl-3-phenylpropylamine (CAS 22374-89-6)

1-Methyl-3-phenylpropylamine (CAS number: 22374-89-6), also widely recognized in the pharmaceutical industry as 2-Amino-4-phenylbutane or 4-phenylbutan-2-amine, serves as a pivotal organic building block and pharmaceutical intermediate. Characterized by its primary amine functionality attached to a branched alkyl chain with a terminal phenyl group, this molecule acts as an essential precursor in advanced organic synthesis and key active pharmaceutical ingredient (API) manufacturing pipelines.

As a dedicated chemical manufacturer and exporter, we maintain strict quality control parameters to guarantee batch-to-batch consistency. The physical and chemical profile of our standard commercial supply is summarized below:

Specification Parameter	Technical Detail / Standard Value
IUPAC Name	4-phenylbutan-2-amine
Common Names	1-Methyl-3-phenylpropylamine, 2-Amino-4-phenylbutane
CAS Registry Number	22374-89-6
Molecular Formula	C10H15N
Molecular Weight	149.23 g/mol
Assay (HPLC/GC)	≥ 98.0% (Custom high purity ≥ 99.0% available)
Appearance	Clear colorless to pale yellow liquid / low-melting solid
Boiling Point	Approx. 220.0 °C to 222.0 °C at 760 mmHg
Density	Approx. 0.938 g/cm³
Solubility	Miscible in common organic solvents (Ethanol, Ether, Dichloromethane)
Standard Packaging	1 kg/bottle, 25 kg/fluorinated drum, or custom 200 kg steel drums

Understanding the precise physical attributes of CAS 22374-89-6 is vital for reaction yield optimization in organic synthesis laboratories. By supplying product with verified purity metrics, we help CRO, CMO, and industrial partners eliminate unwanted side-reaction products and achieve predictable synthetic pathways.

Key Pharmaceutical and Industrial Applications

The synthetic versatility of 1-Methyl-3-phenylpropylamine makes it a sought-after compound across multi-step pharmaceutical development and fine chemical synthesis. Its stereochemical flexibility and reactive amine moiety allow synthetic chemists to utilize it in diverse condensation, alkylation, and acylation reactions.

1. API Intermediate and Drug Discovery

In modern medicinal chemistry, molecules featuring the phenyl-alkylamine backbone frequently exhibit biological activity across central nervous system (CNS) targets, cardiovascular formulations, and receptor modulators. 1-Methyl-3-phenylpropylamine serves as a critical synthon for constructing complex amine derivatives, pharmaceutical ligands, and active drug substance candidates undergoing preclinical and clinical trials.

2. Fine Chemical Building Blocks & Asymmetric Synthesis

Beyond medicinal applications, researchers utilize CAS 22374-89-6 as a chiral precursor or starting material for resolving agents, specialty catalysts, and custom functional chemicals. The amine group easily undergoes transformations into amides, secondary/tertiary amines, or heterocyclic structures required in agricultural formulations and specialty polymers.

3. Custom Synthesis Projects

Our R&D team regularly supports clients who incorporate 2-Amino-4-phenylbutane into proprietary downstream pathways. Whether you are scaling up a preliminary lab route or optimizing a pilot-plant process, having a steady, high-purity supply of this primary intermediate prevents process bottlenecks and ensures reproducible chemical kinetics.

Synthetic Routes and Manufacturing Quality Control

Commercial demand for 1-Methyl-3-phenylpropylamine (CAS 22374-89-6) requires scalable, environmentally responsible, and cost-effective synthetic methods. Our production facilities employ optimized reaction cascades to ensure continuous bulk availability without compromising chemical purity.

General Synthetic Strategy

The classical industrial route to 1-Methyl-3-phenylpropylamine involves the reductive amination of 4-phenyl-2-butanone (benzylacetone) using nitrogen donors under catalytic hydrogenation conditions, or via Leuckart reaction pathways.

4-phenyl-2-butanone + Ammonia / Amine Donor + Catalyst / Reducing Agent ===> 1-Methyl-3-phenylpropylamine (CAS 22374-89-6)

By refining the temperature profiles, catalyst selection, and downstream distillation parameters, our technical team suppresses formation of dimeric impurities and unreacted ketone starting materials.

Quality Assurance and Analytical Validation

Quality is the cornerstone of pharmaceutical supply chain security. Every production batch of CAS 22374-89-6 undergoes rigorous analytical testing prior to release from our facility:

High-Performance Liquid Chromatography (HPLC) & Gas Chromatography (GC): Confirms chemical purity and quantifies volatile impurities.
Proton Nuclear Magnetic Resonance (1H-NMR) & FTIR: Validates structural identity and functional group integrity.
Karl Fischer Titration: Ensures strict control over residual moisture content.
Heavy Metals and Loss on Drying (LOD): Verified to conform with international compendial standards.

Every shipment comes complete with a lot-specific Certificate of Analysis (COA) detailing these exact metrics.

Global Supply Chain, Packaging & Safe Handling Standards

Transporting organic intermediates globally demands strict adherence to international shipping codes, hazardous materials safety, and customized packaging solutions. As an established global exporter, we provide seamless logistics tailored to destination country requirements.

Packaging Options for Every Scale

R&D & Pilot Scale: 100g, 500g, 1kg, and 5kg high-density polyethylene (HDPE) bottles or aluminum containers protected inside insulated tamper-evident boxes.
Commercial Bulk Supply: 25kg fluorinated drums or UN-approved 200kg steel-plastic composite drums, palletized and shrink-wrapped for international freight.
Custom Containers: Available upon request for automated dosing systems in large-scale production facilities.

Logistics and Customs Management

We export 1-Methyl-3-phenylpropylamine to key markets across North America, Europe, Asia-Pacific, and South America. Our export logistics team prepares all shipping declarations, HS code classifications, commercial invoices, packing lists, and safety documentation in advance to guarantee smooth customs clearance.

Handling and Storage Guidelines

1-Methyl-3-phenylpropylamine should be stored in a cool, dry, and well-ventilated warehouse, strictly separated from strong oxidizing agents, acids, and heat sources. Keep containers tightly closed when not in use. Detailed personal protective equipment (PPE) requirements, handling precautions, and spill control measures are documented in our Material Safety Data Sheet (MSDS/SDS), which is included with every order.

Why Partner With Us as Your CAS 22374-89-6 Supplier?

Selecting the right chemical vendor goes beyond comparing unit prices. It requires choosing a partner capable of guaranteeing long-term purity consistency, reliable delivery schedules, and transparent technical communication.

Here is why global pharmaceutical companies, CMOs, and chemical distributors rely on our supply platform:

Factory-Direct Competitive Pricing: By eliminating unnecessary brokers, we deliver direct cost savings for both spot orders and long-term supply contracts.
Flexible Order Quantities: We welcome small R&D sample evaluations as warmly as multi-ton commercial procurement contracts.
Comprehensive Technical Support: Our chemical engineers and QA staff are ready to assist with technical queries, analytical method validation, and custom synthesis specifications.
Transparent Documentation: Download COA, MSDS, and analytical spectra (NMR/HPLC) directly upon request before placing your order.
Secure Global Shipping: Strategic partnerships with major international couriers and air/sea freight forwarders ensure fast, compliant delivery to your door.

How to Buy 1-Methyl-3-phenylpropylamine (Inquiry & Ordering Guide)

Ordering 1-Methyl-3-phenylpropylamine (CAS 22374-89-6) from our platform is designed to be fast, clear, and straightforward for corporate procurement teams.

Step 1: Submit Your Inquiry

Click the button below or email our sales desk directly. Please specify your required purity level, quantity (e.g., 1kg, 25kg, 500kg), destination country, and any special analytical requirements.

Step 2: Commercial Quote & COA Verification

Our sales engineering team will respond within 12 hours with a comprehensive quotation including unit price, lead time, freight cost, and a batch-specific COA for your evaluation.

Step 3: Sample Testing & Order Confirmation

For new partners, sample packages are dispatched rapidly via express air courier (DHL/FedEx) for laboratory testing. Once validated, bulk production or immediate warehouse dispatch begins upon order confirmation.

Step 4: Dispatch & Tracking

Upon shipment, you receive complete tracking details alongside shipping documents to keep your procurement timeline fully transparent.

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Contact our sales team today for current stock levels, custom packaging options, and tier-discounted volume pricing.

References

National Center for Biotechnology Information (NCBI). PubChem Compound Summary for CID 519890, 1-Methyl-3-phenylpropylamine (CAS 22374-89-6). Retrieved from https://pubchem.ncbi.nlm.nih.gov/
European Chemicals Agency (ECHA). Substance Information and Classification: 2-Amino-4-phenylbutane (EC 244-938-0 / CAS 22374-89-6). ECHA Scientific Database.
Royal Society of Chemistry (RSC). ChemSpider Database record for 4-Phenylbutan-2-amine (CSID: 453531). Royal Society of Chemistry.
Smith, M. B., & March, J. (2007). March’s Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (6th ed.). Wiley-Interscience. (Section: Reductive Amination of Ketones and Aldehydes).

标签：1-Methyl-3-phenylpropylamine