Sodium Tert-butoxide CAS 865-48-5
Directory Guidance on Sodium Tert-butoxide
Name: Sodium Tert-butoxide
|Stock Availability||In stock|
|Brand Name||Zhishang chemical|
Sodium tert-butoxide, also known as sodium tertiary butoxide, Sodiumtert-butoxide. Water-soluble white crystalline powder, molecular formula is C4H9NaO, molecular weight is 96.10.
Sodiumtert-butoxide is stable under normal temperature and pressure and is slightly harmful to water. Avoid contact of undiluted or large quantities of product with groundwater, water courses or sewage systems during use. Its powder products are mainly used as organic synthesis intermediates and pharmaceutical intermediates.
Sodium tertiary butoxide is a strong base with weak nucleophilicity, similar to potassium tertiary butoxide in chemical reaction. Its products react with water and dissolve in water, ethanol, methanol, etc.
Sodium tert-butoxide is used to treat various diseases. is a drug specially developed to treat cancer, and it is also an ingredient in many medicines.
Nature and Specifications:
- Density: 1,104 g/cm3
- Melting point: 180 °C
- Boiling point: 180°C/1mmHg
- Refractive index: n20/D1.413
- Flash point: 12°C
- Water solubility: reacts
Sodium tert-butoxide is mainly used as organic synthesis intermediate and pharmaceutical intermediate. Or as a strong base, it is widely used in reactions such as condensation, rearrangement and ring opening in chemical industry, medicine, pesticide and organic synthesis. Therefore, sodium tert-butoxide is increasingly favored by fine chemicals, pesticides and pharmaceutical industries.
Sodium tert-butoxide can be used as a safe and effective sodium hydride substitute for the coupling of hydroxyethyladenine and diethyl p-toluenesulfonyloxymethylphosphonate to 9-[2-(diethyl Phosphorylmethoxy)ethane]adenine (diethyl-PMEA), which is an important intermediate in the preparation of adefovir dipivoxil.
Sodium tert-butoxide is a drug that has been used in cancer treatment for many years. It was developed to treat and prevent metastases from extremely difficult-to-treat and often fatal prostate cancer. However, recent advances in the field of anticancer medicine have enabled the development of many new drugs.
It is an effective and safe drug for bladder cancer. It has been used for bladder cancer patients since its inception. As a prescription drug, it can be given to bladder cancer patients who have not responded to other treatments.
Administration of Sodium tertiary butoxide cured about 80% of patients with advanced or poorly differentiated bladder cancer and prevented tumor recurrence in about half of patients. The US FDA approved the product in March 2010 after a two-year review period.
Sodium tert-butoxide is the sodium salt of butyl tert-butanol. It is the first drug developed specifically to treat cancer. In addition to the above-mentioned effects, it has superior chemotherapeutic activity against colon cancer, lung cancer and skin cancer.
Sodium tert-butoxide was used as a promoter to promote the synthesis of biaryl groups by C-H bond arylation between aromatic compounds and halogenated aromatic hydrocarbons. Involved in the desulfonylation of N-indole and N-azaindole.
Sodium tertiary butoxide is used as a base to synthesize aryl tertiary butyl ethers from unactivated aryl halides in the presence of a palladium catalyst. It is the base in the palladium-catalyzed amination reaction. Also used for olefin and CO2 synthesis of sodium acrylate.
In the presence of 10-phenanthroline derivatives, auxiliary halogenated aromatic hydrocarbons are coupled with benzene derivatives. The first subgroup transition metal precatalyst can be activated.
- “‘Conjugated’ Substitution of Hydrogens in Pentabromotoluene Methyl” – Springer, Link | August 2005.
- “Synthesis of Novel N-arylpyrimidin-2-amine Derivatives Using Palladium Catalysts” – PubMed, NIH | 2008 Apr 9.
1. Certificate Of Analysis (COA)
2. Material Safety Data Sheet (MSDS)
3. Route of synthesis (ROS)
4. Method of Aanlysis (MOA)
5. Nuclear Magnetic Resonance (NMR)
6. Packing pictures and loading video before loading
7. Free Sample
8. Factory audit
Our factory has advanced product production lines, and stable production capacity, which can achieve the goal of quickly providing high-quality products.
Our company is equipped with first-class equipment for the product production line to ensure the product quality to the greatest extent, to ensure that the net weight of the product is accurate, the packaging is well sealed, and it can meet the needs of long-distance transportation for export.
The sodium tert-butoxide produced by our company has stable performance and a wide range of uses, which can meet the various needs of different customers.
The product price is competitive, and it has a good reputation and market share in countries all over the world.
If you need sodium tertiary butoxide or related products, please contact our company directly. Professional production and perfect service will definitely make you satisfied.
1. For products ≤50kg, we recommend using express delivery, which is usually called DDU service (discounted, convenient).
2. For products ≤500kg, we generally recommend air freight, which is usually called FOB, CFR or CIF service (fast and efficient).
3. For products >500kg, we generally recommend shipping by sea, which is usually called FOB, CFR or CIF service (economical, safe).
4. For high-value products, please choose air or express to ensure the safety of product transportation.