Bulk GHK-cu Powder Manufacturer (CAS 49557-75-7) | High Purity Copper Peptide Supplier

Bulk GHK-cu Powder Manufacturer (CAS 49557-75-7) | High Purity Copper Peptide Supplier

CAS 49557-75-7 | GHK-cu

CAS No:49557-75-7
Formula:C14H24N6O4
EINECS:1592732-453-0
Stock Availability:In stock
Brand Name:Zhishang New Materials
Origin:China

Product Introduction of GHK-cu

GHK-cu (CAS 49557-75-7), chemically designated as Copper Tripeptide-1 or Glycyl-L-histidyl-L-lysine copper complex, is a widely recognized bioactive peptide complex utilized extensively in cosmetic formulations, topical skin care research, and advanced cosmetic chemistry. Formed by the high-affinity chelation of a naturally occurring tripeptide with a divalent copper ion (Cu2+), GHK-cu requires exceptional process control during synthesis to guarantee consistent batch purity and structural integrity. At Shandong Zhishang New Materials Co., Ltd., we specialize in the custom synthesis and bulk manufacturing of premium-grade GHK-cu powder, meeting the stringent quality criteria required by international brand formulators and commercial procurement networks.

Technical Specifications & Analytical Parameters

When procuring peptide raw materials, analytical precision and chemical stability are critical. Our manufacturing plant operates state-of-the-art solid-phase peptide synthesis (SPPS) equipment paired with post-synthesis liquid chelation techniques. Every batch of GHK-cu undergoes rigorous quality control, including High-Performance Liquid Chromatography (HPLC), Mass Spectrometry (MS), and Atomic Absorption Spectroscopy (AAS) to measure copper content and free ion levels.

  • Chemical Name: GHK-cu (Copper Tripeptide-1)

  • CAS Registry Number: 49557-75-7

  • Molecular Formula: C14H22CuN6O4

  • Molecular Weight: 401.91 g/mol

  • Appearance: Deep blue crystalline lyophilized powder

  • Peptide Purity (HPLC): >= 98.0%

  • Copper Content (AAS): 5.0% – 7.0%

  • Free Copper Ions (Cu2+): <= 0.1%

  • Water Content (Karl Fischer): <= 5.0%

  • Solubility: Fully soluble in water and aqueous buffers

Product Packaging

Bulk GHK-cu Powder Manufacturer (CAS 49557-75-7) | High Purity Copper Peptide Supplier
We support scalable purchasing from lab-scale R&D to commercial manufacturing. Our standard sample MOQ starts at 10g to 100g in sealed glass bottles or aluminum foil pouches, with commercial packaging available in 1kg to 10kg custom containers.

The characteristic deep blue tint comes directly from the d-d electron transition of the bound copper (Cu2+) ion within the tripeptide chelate ring. Our standardized synthesis ensures consistent molar copper binding, delivering uniform color intensity across all production batches.

For long-term storage prior to formulation, sealed containers of GHK-cu lyophilized powder should be stored away from light and moisture at 2 to 8 degrees Celsius (refrigerated) or -20 degrees Celsius for extended shelf-life exceeding 24 months.

We provide complete chemical compliance documentation, including global transport safety declarations, non-hazardous chemical classification certificates, MSDS in compliance with GHS standards, and batch COAs.

Manufacturing Quality & Supply Chain Advantages

Sourcing high-value peptide raw materials requires a supplier with verifiable quality control and robust manufacturing capabilities. Choosing Shandong Zhishang New Materials as your GHK-cu supply chain partner offers definitive advantages:

  1. Controlled Chelation & Low Free Copper: Improper chelation can lead to excessive free copper ions in raw powder, which causes precipitation or oxidative instability in finished cosmetic emulsions. Our optimized chelation process ensures bound copper ratios remain within narrow tolerances, maximizing formulation stability.

  2. High-Capacity Freeze-Drying (Lyophilization): Our raw GHK-cu is processed through multi-stage industrial freeze-dryers, yielding a crisp, highly soluble deep blue powder with low residual moisture that dissolves cleanly into aqueous phases without clumping.

  3. Batch Traceability & Full Documentation: Every commercial batch is supplied with an exhaustive Certificate of Analysis (COA), HPLC spectrum chromatogram, Material Safety Data Sheet (MSDS), and microbial limit testing reports.

Manufacturer of GHK-cu

📝API, usually referring to chemical raw materials, is the active ingredient in chemical drug formulations.

Formulation Guidelines & Processing Recommendations

GHK-cu is an active cosmetic ingredient sensitive to environmental parameters during compounding. Formulators and batch compounding engineers should account for the following chemical behavior:

  • Temperature Control: GHK-cu should be added during the cool-down phase of emulsion manufacturing (typically below 40 degrees Celsius) to prevent thermal degradation of the peptide chain.

  • Optimal pH Spectrum: Maintain the final product formulation within a neutral pH range of 5.5 to 7.0. Acidic environments (pH below 4.5) can cause the copper ion to dissociate from the tripeptide complex.

  • Incompatibility Considerations: Avoid combining raw GHK-cu in solution with strong chelating agents (such as high concentrations of Disodium EDTA), strong reducing agents, or unstable ascorbic acid derivatives, as these can strip the bound copper or alter chemical structure.

OrganicIntermediate

OrganicIntermediate is a professional foreign trade enterprise specializing in chemical raw materials. Upholding people-oriented values and cooperating with reliable manufacturers, we aim to become the world’s most trusted chemical supplier. Our production plant is located 50 meters south of the intersection of North Ring Road and 13th Road, Chenwang Street, Juancheng County, Heze City, Shandong Province. Our R&D laboratory is situated at R&D Base : F5, Yinfeng Biomedical City, Free Trade Zone, Jinan, Shandong. Integrating R&D and production, we strictly control product quality. With stable supply and sincere service, we welcome global customers for consultation and procurement.

Our Laboratory
Laboratory and Gas Chromatograph at Shandong Zhishang New Materials Co., Ltd.
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The factory of Shandong Zhishang New Materials Co., Ltd.
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